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1

CYP2D6, SULT1A1 and UGT2B17 copy number variation: quantitative detection by multiplex PCR

Gaedigk, Andrea, Twist, Greyson P, Leeder, J Steven

Journal:

Pharmacogenomics

Year:

2012

Language:

english

File:

PDF, 1.90 MB

english, 2012

2

TheCYP2D6gene locus in South African Coloureds: unique allele distributions, novel alleles and gene arrangements

Andrea Gaedigk, Christa Coetsee

Journal:

European Journal of Clinical Pharmacology

Year:

2008

Language:

english

File:

PDF, 412 KB

english, 2008

3

Cytochrome P4502C9 (CYP2C9) allele frequencies in Canadian Native Indian and Inuit populations

Gaedigk, Andrea, Casley, William L, Tyndale, Rachel F, Sellers, Edward M, Jurima-Romet, Malle, Leeder, J Steven

Journal:

Canadian Journal of Physiology and Pharmacology

Year:

2001

File:

PDF, 148 KB

2001

4

NAD(P)H:quinone oxidoreductase: polymorphisms and allele frequencies in Caucasian, Chinese and Canadian Native Indian and Inuit populations

Gaedigk, Andrea, Tyndale, Rachel F., Jurima-Romet, Malle, Sellers, Edward M., Grant, Denis M., Leeder, J Steven

Journal:

Pharmacogenetics

Year:

1998

File:

PDF, 762 KB

1998

5

Defining Risk Factors for Red Man Syndrome in Children and Adults

Myers, Angela L., Gaedigk, Andrea, Dai, Hongying, James, Laura P., Jones, Bridgette L., Neville, Kathleen A.

Journal:

Pediatric Infectious Disease Journal

Year:

2012

Language:

english

File:

PDF, 130 KB

english, 2012

6

CYP2D6 genotype analysis of a Thai population: platform comparison

Chamnanphon, Monpat, Gaedigk, Andrea, Vanwong, Natchaya, Nuntamool, Nopphadol, Hongkaew, Yaowaluck, Puangpetch, Apichaya, Sukasem, Chonlaphat

Journal:

Pharmacogenomics

Year:

2018

Language:

english

File:

PDF, 433 KB

english, 2018

7

Pharmacogene Variation in Thai Plasmodium vivax Relapse Patients Treated with a Combination of Primaquine and Chloroquine

Chamnanphon, Monpat, Gaedigk, Andrea, Puangpetch, Apichaya, Pasomsub, Ekawat, Chantratita, Wasun, Longley, Rhea J, Sattabongkot, Jetsumon, Chariyavilaskul, Pajaree, Sukasem, Chonlaphat

Journal:

Pharmacogenomics and Personalized Medicine

Year:

2020

Language:

english

File:

PDF, 1.69 MB

english, 2020

8

Long-Distance Phasing of a Tentative âEnhancerâ Single-Nucleotide Polymorphism With CYP2D6 Star Allele Definitions

Boone, Erin C., Wang, Wendy Y., Gaedigk, Roger, Cherner, Mariana, BÃ©rard, Anick, Leeder, J. Steven, Miller, Neil A., Gaedigk, Andrea

Journal:

Frontiers in Pharmacology

Year:

2020

File:

PDF, 697 KB

2020

9

Interindividual variability in acetaminophen sulfation by human fetal liver: Implications for pharmacogenetic investigations of drug-induced birth defects

Araba A. Adjei, Andrea Gaedigk, Stephen D. Simon, Richard M. Weinshilboum, J. Steven Leeder

Journal:

Birth Defects Research Part A: Clinical and Molecular Teratology

Year:

2008

Language:

english

File:

PDF, 409 KB

english, 2008

10

Limited Association of the 2988g>a Single Nucleotide Polymorphism with CYP2D6*41 in Black Subjects

Gaedigk, Andrea, Ndjountché, Liliane, Leeder, J. Steven, Bradford, L. DiAnne

Journal:

Clinical Pharmacology & Therapeutics

Year:

2005

Language:

english

File:

PDF, 141 KB

english, 2005

11

Chiral phase analysis of warfarin enantiomers in patient plasma in relation to CYP2C9 genotype

Kirk R Henne, Andrea Gaedigk, Ganesh Gupta, J.Steven Leeder, Allan E Rettie

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1998

Language:

english

File:

PDF, 78 KB

english, 1998

12

Identification ofCYP2D6impaired functional alleles in Mexican Americans

Huai-Rong Luo, Andrea Gaedigk, Vasileios Aloumanis, Yu-Jui Yvonne Wan

Journal:

European Journal of Clinical Pharmacology

Year:

2005

Language:

english

File:

PDF, 178 KB

english, 2005

13

Effects of fluvastatin and cigarette smoking on CYP2C9 activity measured using the probe S-warfarin

Myong-Jin Kim, Anne N. Nafziger, Angela D. M. Kashuba, Julia Kirchheiner, Steffen Bauer, Andrea Gaedigk, Joseph S. Bertino

Journal:

European Journal of Clinical Pharmacology

Year:

2006

Language:

english

File:

PDF, 127 KB

english, 2006

14

Identification of a novel non-functionalCYP2D6allele,CYP2D6*69, in a Caucasian poor metabolizer individual

Andrea Gaedigk, Dorothee Frank, Uwe Fuhr

Journal:

European Journal of Clinical Pharmacology

Year:

2009

Language:

english

File:

PDF, 107 KB

english, 2009

15

Variability in drug metabolizing enzyme activity in HIV-infected patients

Amanda E. Jones, Kevin C. Brown, Rebecca E. Werner, Karl Gotzkowsky, Andrea Gaedigk, Mike Blake, David W. Hein, Charles van der Horst, Angela D. M. Kashuba

Journal:

European Journal of Clinical Pharmacology

Year:

2010

Language:

english

File:

PDF, 210 KB

english, 2010

16

Discovery of the nonfunctionalCYP2D6*31allele in Spanish, Puerto Rican, and US Hispanic populations

Andrea Gaedigk, Maria Isidoro-García, Robin E. Pearce, Santiago Sánchez, Virginia García-Solaesa, Carolina Lorenzo-Romo, Gloria Gonzalez-Tejera, Susan Corey

Journal:

European Journal of Clinical Pharmacology

Year:

2010

Language:

english

File:

PDF, 140 KB

english, 2010

17

Erratum to: Discovery of the nonfunctional CYP2D6*31 allele in Spanish, Puerto Rican, and US Hispanic populations

Andrea Gaedigk, Maria Isidoro-García, Robin E. Pearce, Santiago Sánchez, Virginia García-Solaesa, Carolina Lorenzo-Romo, Gloria Gonzalez-Tejera, Susan Corey

Journal:

European Journal of Clinical Pharmacology

Year:

2011

Language:

english

File:

PDF, 48 KB

english, 2011

18

Elucidation of CYP2D6 Genetic Diversity in a Unique African Population: Implications for the Future Application of Pharmacogenetics in the Xhosa Population

Galen E. B. Wright, Dana J. H. Niehaus, Britt I. Drögemöller, Liezl Koen, Andrea Gaedigk, Louise Warnich

Journal:

Annals of Human Genetics

Year:

2010

Language:

english

File:

PDF, 420 KB

english, 2010

19

Identification of the primary gene defect at the cytochrome P450 CYP2D locus

Gough, Alan C., Miles, John S., Spurr, Nigel K., Moss, Julie E., Gaedigk, Andrea, Eichelbaum, Michel, Wolf, C. Roland

Journal:

Year:

1990

File:

PDF, 555 KB

1990

20

Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans*

Gaedigk, Andrea, Bradford, L. DiAnne, Marcucci, Kenda A., Leeder, J. Steven

Journal:

Clinical Pharmacology & Therapeutics

Year:

2002

Language:

english

File:

PDF, 228 KB

english, 2002

21

Effect of sex and menstrual cycle phase on cytochrome P450 2C19 activity with omeprazole used as a biomarker

Kim, Myong-Jin, Bertino, Joseph S., Gaedigk, Andrea, Zhang, Yanhua, Sellers, Edward M., Nafziger, Anne N.

Journal:

Clinical Pharmacology & Therapeutics

Year:

2002

Language:

english

File:

PDF, 122 KB

english, 2002

22

Novel sulfotransferases cloned by RT-PCR: real proteins or PCR artifacts?

Andrea Gaedigk, Poli Lekas, Miriam Berchuk, Denis M Grant

Journal:

Chemico-Biological Interactions

Year:

1998

Language:

english

File:

PDF, 195 KB

english, 1998

23

Human acetyltransferase polymorphisms

Denis M Grant, Nicola C Hughes, Susan A Janezic, Geoffrey H Goodfellow, Hillary J Chen, Andrea Gaedigk, Violeta L Yu, Ranbir Grewal

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1997

Language:

english

File:

PDF, 404 KB

english, 1997

24

The role of xenobiotic metabolizing enzymes in arylamine toxicity and carcinogenesis: Functional and localization studies

Kelly F Windmill, Ross A McKinnon, Xiaoyi Zhu, Andrea Gaedigk, Denis M Grant, Michael E McManus

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1997

Language:

english

File:

PDF, 540 KB

english, 1997

25

CYP2D6 Inhibition by Selective Serotonin Reuptake Inhibitors: Analysis of Achievable Steady-State Plasma Concentrations and the Effect of Ultrarapid Metabolism at CYP2D6

Dr. Y. W. Francis Lam, Dr. Andrea Gaedigk, Dr. Larry Ereshefsky, Dr. Cara L. Alfaro, Dr. Joe Simpson

Journal:

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy

Year:

2002

Language:

english

File:

PDF, 40 KB

english, 2002

26

Cloning, Structural Organization, and Chromosomal Mapping of the Human Phenol SulfotransferaseSTP2Gene

Andrea Gaedigk, Barbara G. Beatty, Denis M. Grant

Journal:

Year:

1997

Language:

english

File:

PDF, 235 KB

english, 1997

27

Crystal structure of human catecholamine sulfotransferase

Lisa M Bidwell, Michael E McManus, Andrea Gaedigk, Yoshimitsu Kakuta, Masa Negishi, Lars Pedersen, Jennifer L Martin

Journal:

Journal of Molecular Biology

Year:

1999

Language:

english

File:

PDF, 480 KB

english, 1999

28

Genetic analysis of microsomal epoxide hydrolase in patients with carbamazepine hypersensitivity

Victoria J. Green, Munir Pirmohamed, Neil R. Kitteringham, Andrea Gaedigk, Denis M. Grant, Maureen Boxer, Brian Burchell, B.Kevin Park

Journal:

Biochemical Pharmacology

Year:

1995

Language:

english

File:

PDF, 1007 KB

english, 1995

29

CYP2D7 splice variants in human liver and brain: Does CYP2D7 encode functional protein?

Andrea Gaedigk, Roger Gaedigk, J. Steven Leeder

Journal:

Biochemical and Biophysical Research Communications

Year:

2005

Language:

english

File:

PDF, 379 KB

english, 2005

30

Six-month, prospective, longitudinal, open-Label caffeine and dextromethorphan phenotyping study in children with growth hormone deficiency receiving recombinant human growth hormone replacement

Mary Jayne Kennedy, Daniel A. Davis, Ned Smith, Andrea Gaedigk, Robin E. Pearce, Gregory L. Kearns

Journal:

Clinical Therapeutics

Year:

2008

Language:

english

File:

PDF, 921 KB

english, 2008

31

The neuroprotective enzyme CYP2D6 increases in the brain with age and is lower in Parkinson's disease patients

Amandeep Mann, Sharon L. Miksys, Andrea Gaedigk, Stephen J. Kish, Deborah C. Mash, Rachel F. Tyndale

Journal:

Neurobiology of Aging

Year:

2012

Language:

english

File:

PDF, 3.18 MB

english, 2012

32

Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother

Gideon Koren, James Cairns, David Chitayat, Andrea Gaedigk, Steven J Leeder

Journal:

Year:

2006

Language:

english

File:

PDF, 43 KB

english, 2006

33

CYP2D7–2D6 hybrid tandems: identification of novel CYP2D6 duplication arrangements and implications for phenotype prediction

Gaedigk, Andrea, Fuhr, Uwe, Johnson, Charlene, Bérard, Anick, Bradford, L DiAnne, Leeder, J Steven

Journal:

Pharmacogenomics

Year:

2010

Language:

english

File:

PDF, 1.62 MB

english, 2010

34

Detection and characterization of the CYP2D6*9x2 gene duplication in two Spanish populations: resolution of AmpliChip CYP450 test no-calls

Gaedigk, Andrea, Hernandez, Juanjo, García-Solaesa, Virginia, Sánchez, Santiago, Isidoro-García, Maria

Journal:

Pharmacogenomics

Year:

2011

Language:

english

File:

PDF, 924 KB

english, 2011

35

Characterization of the CYP2D6 gene locus and metabolic activity in Indo- and Afro-Trinidadians: discovery of novel allelic variants

Montané Jaime, Lazara Karelia, Lalla, Anthony, Steimer, Werner, Gaedigk, Andrea

Journal:

Pharmacogenomics

Year:

2013

Language:

english

File:

PDF, 1.20 MB

english, 2013

36

High-resolution melt analysis to detect sequence variations in highly homologous gene regions: application to CYP2B6

Twist, Greyson P, Gaedigk, Roger, Leeder, J Steven, Gaedigk, Andrea

Journal:

Pharmacogenomics

Year:

2013

Language:

english

File:

PDF, 1020 KB

english, 2013

37

Effect ofCYP3A5genotype, steroids, and azoles on tacrolimus in a pediatric renal transplant population

Lalan, Shwetal, Abdel-Rahman, Susan, Gaedigk, Andrea, Leeder, J. Steven, Warady, Bradley A., Dai, Hongying, Blowey, Douglas

Journal:

Pediatric Nephrology

Year:

2014

Language:

english

File:

PDF, 1.89 MB

english, 2014

38

Complexities of CYP2D6 gene analysis and interpretation

Gaedigk, Andrea

Journal:

International Review of Psychiatry

Year:

2013

Language:

english

File:

PDF, 578 KB

english, 2013

39

CYP2D6 and pharmacogenomics: where does future research need to focus? Part 1: technical aspects

Gaedigk, Andrea, Leeder, J Steven

Journal:

Pharmacogenomics

Year:

2014

Language:

english

File:

PDF, 943 KB

english, 2014

40

CYP2D6 and pharmacogenomics: where does future research need to focus? Part 2: clinical aspects

Leeder, J Steven, Gaedigk, Andrea

Journal:

Pharmacogenomics

Year:

2014

Language:

english

File:

PDF, 1.39 MB

english, 2014

41

Evaluation of a [ 13 C]-Dextromethorphan Breath Test to Assess CYP2D6 Phenotype

Leeder, J. Steven, Pearce, Robin E., Gaedigk, Andrea, Modak, Anil, Rosen, David I.

Journal:

Journal of Clinical Pharmacology

Year:

2008

Language:

english

File:

PDF, 628 KB

english, 2008

42

Single-Dose Pharmacokinetics of Oral and Intravenous Pantoprazole in Children and Adolescents

Kearns, Gregory L., Blumer, Jeffrey, Schexnayder, Stephen, James, Laura P., Adcock, Kim G., Reed, Michael D., Daniel, James F., Gaedigk, Andrea, Paul, Jeffrey

Journal:

Journal of Clinical Pharmacology

Year:

2008

Language:

english

File:

PDF, 190 KB

english, 2008

43

Tissue-Specific Expression and Alternative Splicing of Human Microsomal Epoxide Hydrolase

GAEDIGK, ANDREA, LEEDER, J. STEVEN, GRANT, DENIS M.

Journal:

DNA and Cell Biology

Year:

1997

Language:

english

File:

PDF, 6.55 MB

english, 1997

44

Detection of an endogenous urinary biomarker associated with CYP2D6 activity using global metabolomics

Tay-Sontheimer, Jessica, Shireman, Laura M, Beyer, Richard P, Senn, Taurence, Witten, Daniela, Pearce, Robin E, Gaedigk, Andrea, Gana Fomban, Cletus L, Lutz, Justin D, Isoherranen, Nina, Thummel, Kenn

Journal:

Pharmacogenomics

Year:

2014

Language:

english

File:

PDF, 1.71 MB

english, 2014

45

Omeprazole Disposition in Children following Single-Dose Administration

Kearns, Gregory L., Andersson, Tommy, James, Laura P., Gaedigk, Andrea, Kraynak, Rebecca A., Abdel-Rahman, Susan M., Ramabadran, Krishnaswami, van den Anker, John N.

Journal:

Journal of Clinical Pharmacology

Year:

2003

Language:

english

File:

PDF, 111 KB

english, 2003

46

UGT2B17 and SULT1A1 gene copy number variation (CNV) detection by LabChip microfluidic technology

Gaedigk, Andrea, Gaedigk, Roger, Leeder, J. Steven

Journal:

Clinical Chemistry and Laboratory Medicine

Year:

2010

Language:

english

File:

PDF, 223 KB

english, 2010

47

Characterization of a complex CYP2D6 genotype that caused an AmpliChip CYP450 Test® no-call in the clinical setting

Gaedigk, Andrea, Riffel, Amanda K., Berrocal, Belén García, Solaesa, Virginia García, Dávila, Ignacio, Isidoro-García, María

Journal:

Clinical Chemistry and Laboratory Medicine

Year:

2014

Language:

english

File:

PDF, 525 KB

english, 2014

48

Multiple Dose Pharmacokinetics of Paroxetine in Children and Adolescents with Major Depressive Disorder or Obsessive–Compulsive Disorder

Findling, Robert L, Nucci, Gianluca, Piergies, Antoni A, Gomeni, Roberto, Bartolic, Edward I, Fong, Regan, Carpenter, David J, Leeder, J Steven, Gaedigk, Andrea, Danoff, Theodore M

Journal:

Neuropsychopharmacology

Year:

2005

Language:

english

File:

PDF, 168 KB

english, 2005

49

SNP genotyping using TaqMan® technology: the CYP2D6*17 assay conundrum

Gaedigk, Andrea, Freeman, Natalie, Hartshorne, Toinette, Riffel, Amanda K., Irwin, David, Bishop, Jeffrey R., Stein, Mark A., Newcorn, Jeffrey H., Jaime, Lazara Karelia Montané, Cherner, Mariana, Leed

Journal:

Scientific Reports

Year:

2015

Language:

english

File:

PDF, 1.63 MB

english, 2015

50

Genetic determinants of variable metabolism have little impact on the clinical use of leading antipsychotics in the CATIE study

Grossman, Iris, Sullivan, Patrick F, Walley, Nicole, Liu, Youfang, Dawson, Jeffrey R, Gumbs, Curtis, Gaedigk, Andrea, Leeder, J Steven, McEvoy, Joseph P, Weale, Michael E, Goldstein, David B

Journal:

Genetics in Medicine

Year:

2008

Language:

english

File:

PDF, 571 KB

english, 2008